Animal Model Core
| Director: Lars Eckmann, M.D. | Email: leckmann@ucsd.edu Phone: 858-534-0683 |
Core Purpose
Physiologic studies in murine models are of increasing importance in the discovery of novel mechanisms of gastrointestinal health and disease as the basis for developing improved treatment and prevention strategies. The ability to generate genetically engineered mice on a routine basis has set the stage for a new era of "molecular physiology." Yet, the generation of new genetic mouse models has outpaced in many instances the ability to investigate the physiologic consequences of specific genetic manipulations. While the production of mutant mice has reached a technical uniformity and maturity that can be handled routinely by dedicated core facilities at the academic or commercial level, the development and application of physiologic mouse models are unique to each organ system. Successful conduct of physiologic studies in gastroenterology requires extensive expertise and significant resources that are not readily available in academic laboratories or commercially. This situation prevents basic science investigators with a focus on specific molecules or signaling processes to apply their insights to gastrointestinal physiology and hinders researchers with a focus on physiologic events to examine the molecular underpinnings of such events. C-TREAT's Animal Model Core will bridge the gap between molecular and physiologic research.
Core Services
- Assistance in conduct and analysis of animal studies.
- Breeding Colony Support.
- Advice and training in animal research.
